Among COX-2 user (e.g., Celebrex, Vioxx, and Bextra, n=38) esomeprazole maintain a pH of greater than 4.0 for 17.5 hours associate with 16.1 hours for lansoprazole and 14.6 hours for pantoprazole. Among users of nonselective NSAIDs (e.g., ibuprofen, naproxen, n=39) esomeprazole maintained a pH of greater than 4.0 for 18.1 hours compared with 15.8 for lansoprazole and 14.6 hours for pantoprazole.
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